The College of Science is one of the largest colleges of the university in terms of the number of students and faculty members. It was established in 1431 AH, and since its establishment, it has been able to achieve a distinguished position thanks to the high quality of education and scientific research, in addition to the diversity of the academic programs it offers.
The academic programs in the college vary to include the undergraduate and graduate levels, in addition to diploma programs, reflecting the college's commitment to providing comprehensive education that meets the different needs of students. The college also contributes to enriching knowledge by organizing scientific activities, conferences, seminars, and workshops that contribute to creating a vibrant and advanced scientific environment within the college.
The college includes several distinguished scientific departments that vary in different specializations, reflecting the comprehensiveness of its education and the diversity of its research fields.

The College of Science has taken the initiative to apply modern technologies in the educational process and electronic tests to keep pace with global scientific development. The college also seeks to improve the quality of education by using innovative educational tools and enhancing the digital learning experience, which contributes to preparing students to face the challenges of the modern era. The college is constantly working to achieve the goals set by the university, in line with its vision and mission, and to contribute to making Jeddah University one of the leading universities at the local, regional, and international levels, thus contributing to achieving the vision of the Kingdom of Saudi Arabia 2030. In addition, the college focuses on enhancing academic cooperation with local and international scientific research institutions, which contributes to the exchange of knowledge and expertise and helps in developing joint research projects. It also seeks to provide advanced training programs for students and faculty members, intending to raise the level of academic and administrative skills in line with market needs and scientific developments.